diff --git a/build/cmake/DefineCMakeDefaults.cmake b/build/cmake/DefineCMakeDefaults.cmake
index 2fe41d3..f41673e 100644
--- a/build/cmake/DefineCMakeDefaults.cmake
+++ b/build/cmake/DefineCMakeDefaults.cmake
@@ -56,3 +56,15 @@
 set(CMAKE_LIBRARY_OUTPUT_DIRECTORY ${CMAKE_BINARY_DIR}/lib)
 set(CMAKE_ARCHIVE_OUTPUT_DIRECTORY ${CMAKE_BINARY_DIR}/lib)
 set(CMAKE_RUNTIME_OUTPUT_DIRECTORY ${CMAKE_BINARY_DIR}/bin)
+
+#
+# "rpath" support.
+# See http://www.itk.org/Wiki/index.php?title=CMake_RPATH_handling
+#
+# On MacOSX, for shared libraries, enable rpath support.
+set(CMAKE_MACOSX_RPATH TRUE)
+#
+# On any OS, for executables, allow linking with shared libraries in non-system
+# locations and running the executables without LD_PRELOAD or similar.
+# This requires the library to be built with rpath support.
+set(CMAKE_INSTALL_RPATH_USE_LINK_PATH TRUE)