diff --git a/tempest/api/compute/base.py b/tempest/api/compute/base.py
index ac03cdc..e208a64 100644
--- a/tempest/api/compute/base.py
+++ b/tempest/api/compute/base.py
@@ -99,6 +99,15 @@
         cls.versions_client = cls.os_primary.compute_versions_client
         if CONF.service_available.cinder:
             cls.volumes_client = cls.os_primary.volumes_client_latest
+        if CONF.service_available.glance:
+            if CONF.image_feature_enabled.api_v1:
+                cls.images_client = cls.os_primary.image_client
+            elif CONF.image_feature_enabled.api_v2:
+                cls.images_client = cls.os_primary.image_client_v2
+            else:
+                raise lib_exc.InvalidConfiguration(
+                    'Either api_v1 or api_v2 must be True in '
+                    '[image-feature-enabled].')
 
     @classmethod
     def resource_setup(cls):
@@ -254,7 +263,11 @@
 
     @classmethod
     def create_image_from_server(cls, server_id, **kwargs):
-        """Wrapper utility that returns an image created from the server."""
+        """Wrapper utility that returns an image created from the server.
+
+        If compute microversion >= 2.36, the returned image response will
+        be from the image service API rather than the compute image proxy API.
+        """
         name = kwargs.pop('name',
                           data_utils.rand_name(cls.__name__ + "-image"))
         wait_until = kwargs.pop('wait_until', None)
@@ -267,14 +280,21 @@
             image_id = image['image_id']
         else:
             image_id = data_utils.parse_image_id(image.response['location'])
+
+        # The compute image proxy APIs were deprecated in 2.35 so
+        # use the images client directly if the API microversion being
+        # used is >=2.36.
+        if api_version_utils.compare_version_header_to_response(
+                "OpenStack-API-Version", "compute 2.36", image.response, "lt"):
+            client = cls.images_client
+        else:
+            client = cls.compute_images_client
         cls.addClassResourceCleanup(test_utils.call_and_ignore_notfound_exc,
-                                    cls.compute_images_client.delete_image,
-                                    image_id)
+                                    client.delete_image, image_id)
 
         if wait_until is not None:
             try:
-                waiters.wait_for_image_status(cls.compute_images_client,
-                                              image_id, wait_until)
+                waiters.wait_for_image_status(client, image_id, wait_until)
             except lib_exc.NotFound:
                 if wait_until.upper() == 'ACTIVE':
                     # If the image is not found after create_image returned
@@ -292,7 +312,11 @@
                             image_id=image_id)
                 else:
                     raise
-            image = cls.compute_images_client.show_image(image_id)['image']
+            image = client.show_image(image_id)
+            # Compute image client returns response wrapped in 'image' element
+            # which is not the case with Glance image client.
+            if 'image' in image:
+                image = image['image']
 
             if wait_until.upper() == 'ACTIVE':
                 if wait_for_server:
diff --git a/tempest/api/compute/flavors/test_flavors_negative.py b/tempest/api/compute/flavors/test_flavors_negative.py
index efd4f0e..3a474e6 100644
--- a/tempest/api/compute/flavors/test_flavors_negative.py
+++ b/tempest/api/compute/flavors/test_flavors_negative.py
@@ -30,18 +30,6 @@
 
 class FlavorsV2NegativeTest(base.BaseV2ComputeTest):
 
-    @classmethod
-    def setup_clients(cls):
-        super(FlavorsV2NegativeTest, cls).setup_clients()
-        if CONF.image_feature_enabled.api_v1:
-            cls.images_client = cls.os_primary.image_client
-        elif CONF.image_feature_enabled.api_v2:
-            cls.images_client = cls.os_primary.image_client_v2
-        else:
-            raise lib_exc.InvalidConfiguration(
-                'Either api_v1 or api_v2 must be True in '
-                '[image-feature-enabled].')
-
     @decorators.attr(type=['negative'])
     @utils.services('image')
     @decorators.idempotent_id('90f0d93a-91c1-450c-91e6-07d18172cefe')
diff --git a/tempest/lib/api_schema/response/compute/v2_45/__init__.py b/tempest/lib/api_schema/response/compute/v2_45/__init__.py
new file mode 100644
index 0000000..e69de29
--- /dev/null
+++ b/tempest/lib/api_schema/response/compute/v2_45/__init__.py
diff --git a/tempest/lib/api_schema/response/compute/v2_45/images.py b/tempest/lib/api_schema/response/compute/v2_45/images.py
new file mode 100644
index 0000000..8a48f36
--- /dev/null
+++ b/tempest/lib/api_schema/response/compute/v2_45/images.py
@@ -0,0 +1,32 @@
+#    Licensed under the Apache License, Version 2.0 (the "License"); you may
+#    not use this file except in compliance with the License. You may obtain
+#    a copy of the License at
+#
+#         http://www.apache.org/licenses/LICENSE-2.0
+#
+#    Unless required by applicable law or agreed to in writing, software
+#    distributed under the License is distributed on an "AS IS" BASIS, WITHOUT
+#    WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. See the
+#    License for the specific language governing permissions and limitations
+#    under the License.
+
+# The 2.45 microversion removes the "location" header and adds "image_id"
+# to the response body.
+create_image = {
+    'status_code': [202],
+    'response_body': {
+        'type': 'object',
+        'properties': {
+            'image_id': {'type': 'string'}
+        },
+        'additionalProperties': False,
+        'required': ['image_id']
+    }
+}
+
+# NOTE(mriedem): The compute proxy APIs for showing/listing and deleting
+# images were deprecated in microversion 2.35, and the compute proxy APIs for
+# working with image metadata were deprecated in microversion 2.39. Therefore,
+# client-side code shouldn't rely on those APIs in the compute images client
+# past those microversions and should instead use the Glance images client
+# directly.
diff --git a/tempest/lib/services/compute/images_client.py b/tempest/lib/services/compute/images_client.py
index 86bea9e..0f4eb42 100644
--- a/tempest/lib/services/compute/images_client.py
+++ b/tempest/lib/services/compute/images_client.py
@@ -17,6 +17,7 @@
 from six.moves.urllib import parse as urllib
 
 from tempest.lib.api_schema.response.compute.v2_1 import images as schema
+from tempest.lib.api_schema.response.compute.v2_45 import images as schemav245
 from tempest.lib.common import rest_client
 from tempest.lib import exceptions as lib_exc
 from tempest.lib.services.compute import base_compute_client
@@ -24,6 +25,10 @@
 
 class ImagesClient(base_compute_client.BaseComputeClient):
 
+    schema_versions_info = [
+        {'min': None, 'max': '2.44', 'schema': schema},
+        {'min': '2.45', 'max': None, 'schema': schemav245}]
+
     def create_image(self, server_id, **kwargs):
         """Create an image of the original server.
 
@@ -36,7 +41,10 @@
         post_body = json.dumps(post_body)
         resp, body = self.post('servers/%s/action' % server_id,
                                post_body)
-        self.validate_response(schema.create_image, resp, body)
+        _schema = self.get_schema(self.schema_versions_info)
+        if body:
+            body = json.loads(body)
+        self.validate_response(_schema.create_image, resp, body)
         return rest_client.ResponseBody(resp, body)
 
     def list_images(self, detail=False, **params):